49ers and Rams on Thursday Night, October 2nd, 2025 – Rams -5.5

The Rams look like legitimate super bowl contenders. The 49ers are dealing with Nick Bosa’s knee injury on top of the QB decision with Brock Purdy’s toe hurting. The 49ers are undefeated with Mac Jones at the wheel. This is where that ends though. The Rams are going to win this game by 10 points or so. It may come down to a last minute drive to cover but there is no reason to think the 49ers can keep pace with Stafford and this stacked offense. This is a pretty easy pick, and I hate that most if not all people will pick the Rams here because that usually spells doom(packers/cowboys game), but just pick the Rams here and be happy when they cover.

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